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Small RNA profiling of differentiated and de-differentiated vascular smooth muscle cell

ABSTRACT: We report the application of small RNA sequencing for high-throughput profiling of small RNA under 75 bp in vascular smooth muscle cell. By a reading depth of 30M and single stranded sequencing, we generated the small RNA signature on differentiated and de-differentiated vascular smooth muscle cell induced by PDGF-BB and H3K4me2 editing. We found that PDGF-BB and H3K4me2 editing induced de-differentiation modulated miRNA profile significantly, which was demonstrated at least in part responsible for modulated vascular smooth muscle cell phenotype.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE186972 | GEO | 2022/04/01

REPOSITORIES: GEO

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