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RNA-Seq of Mytilus galloprovincialis's hepatopancreas

ABSTRACT: Contaminants of Emerging Concern (CECs) are a class of chemicals that can spread throughout the environment causing adverse biological and ecological effects. Through the different classes of CECs, the occurrence of pharmaceutical drugs such as natural and synthetic estrogens, is well documented in the aquatic environment. In this study mussels (Mytilus galloprovincialis), chosen as model organism, were exposed to the synthetic hormone 17 α-Ethinylestradiol (EE2), the primary component in contraceptive pills. Mussels were exposed to a single concentration of EE2 ( 5 ng/L) of EE2 in a semi-static and time-dependent experiment. The total period of exposure was 28 days and the mussels were analysed 14 days (T14) and 28 days (T28) after treatment. RNA-Seq analysis showed signs of stress with significant differential expression at 99 genes (T14 compared to controls), 73 genes (T28 compared to controls) and 103 DEGs after two weeks of exposure. EE2 treatment resulted in up-regulation of 3 gene/proteins for lipid transport/metabolism and 7 gene/proteins upregulated encoding immune and antibacterial function.

ORGANISM(S): Mytilus galloprovincialis

PROVIDER: GSE188198 | GEO | 2022/05/15

REPOSITORIES: GEO

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