Transcriptomics

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RNA profiling of wild-type and hnRNPF-knockout splenic B cells


ABSTRACT: Alternative splicing (AS) plays an important role in the development and activation of B cells. RNA-binding proteins (RBPs) have emerged as critical players in AS regulation. RNA-binding protein hnRNPF regulates AS of several important genes, such as c-Src, Bcl-xl, Mcl-1 and Tcf3 in tumor cells, but its function in B cell biology is not known.Here we constructed CD19-Cre mediated hnRNPF conditional knockou mice and performed RNA-sequencing to profile mRNA expression and AS regulated by hnRNPF in splenic B cells.

ORGANISM(S): Mus musculus

PROVIDER: GSE188538 | GEO | 2022/05/11

REPOSITORIES: GEO

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