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Ptip is essential for tooth development via regulating Wnt pathway

ABSTRACT: Purpose: the goals of this study are to explore the effect of loss of Ptip in Sp7 positive dental progenitor cells on CD45- Ter119- Tie2- dental progenitor cells Methods: CD45- Ter119- Tie2- dental progenitor cells were sorted by FACs in lower incisors from Ptipf/f and Ptipf/f;Sp7-cre mice and performed RNAseq Our finding reveals that Ptip as crucial regulator in tooth homeostasis, functioning to safeguard the Sp7+ progenitor cells epigenome from a breach in lineage confinement that triggers irreversible tooth defects. Conclusions: loss of Ptip unregulate dental development and active Wnt signal pathway

ORGANISM(S): Mus musculus

PROVIDER: GSE188800 | GEO | 2023/04/04

REPOSITORIES: GEO

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Vessel Forming Mesenchymal Stromal Cell Populations

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Ptip is essential for tooth development via regulating Wnt pathway

Project description:Ptip is essential for tooth development via regulating Wnt pathway

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