Transcriptomics

Dataset Information

0

Ptip is essential for tooth development via regulating Wnt pathway


ABSTRACT: Purpose: the goals of this study are to explore the effect of loss of Ptip in Sp7 positive dental progenitor cells on CD45- Ter119- Tie2- dental progenitor cells Methods: CD45- Ter119- Tie2- dental progenitor cells were sorted by FACs in lower incisors from Ptipf/f and Ptipf/f;Sp7-cre mice and performed RNAseq Our finding reveals that Ptip as crucial regulator in tooth homeostasis, functioning to safeguard the Sp7+ progenitor cells epigenome from a breach in lineage confinement that triggers irreversible tooth defects. Conclusions: loss of Ptip unregulate dental development and active Wnt signal pathway

ORGANISM(S): Mus musculus

PROVIDER: GSE188800 | GEO | 2023/04/04

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2023-02-18 | GSE181177 | GEO
2009-05-29 | GSE16263 | GEO
2009-05-29 | E-GEOD-16263 | biostudies-arrayexpress
2021-06-11 | GSE161477 | GEO
2023-07-19 | GSE237439 | GEO
2010-08-25 | E-GEOD-20852 | biostudies-arrayexpress
2022-05-02 | GSE201915 | GEO
2009-10-28 | GSE18778 | GEO
2022-05-23 | GSE203601 | GEO
2010-03-06 | E-GEOD-20570 | biostudies-arrayexpress