Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Primordial germ cells identified as one potential cell of origin of MYC rhabdoid tumors

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE188817 | GEO | 2022/01/28

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Primordial germ cells identified as one potential cell of origin of MYC rhabdoid tumors

Project description:Rhabdoid tumors (RT) are rare and highly aggressive pediatric neoplasms. Their epigenetically-driven intertumoral heterogeneity is well described; however, the cellular origin of RT remains an enigma. Here, we established and characterized different genetically engineered mouse models driven under the control of distinct promoters and being active in early progenitor cell types with diverse embryonic onsets. From all models only Sox2-positive progenitor cells give rise to murine RT. Using single-cell analyses, we identified distinct cells of origin for the SHH and MYC subgroups of RT, rooting in early stages of embryogenesis. Intra- and extracranial MYC tumors harbor common genetic programs and potentially originate from fetal primordial germ cells (PGCs). Using PGC specific Smarcb1 knockout mouse models we validated that MYC RT originate from these progenitor cells. We uncovered an epigenetic imbalance in MYC tumors compared to PGCs being sustained by epigenetically-driven subpopulations. Importantly, treatments with the DNA demethylating agent decitabine successfully impaired tumor growth in vitro and in vivo.

2022-01-28 | GSE188654 | GEO

Primordial germ cells identified as one potential cell of origin of MYC rhabdoid tumors

2022-01-28 | GSE188815 | GEO

Primordial germ cells identified as one potential cell of origin of MYC rhabdoid tumors

2022-01-28 | GSE188816 | GEO

Primordial germ cells identified as one potential cell of origin of MYC rhabdoid tumors

Project description:Primordial germ cells identified as one potential cell of origin of MYC rhabdoid tumors

| PRJNA780430 | ENA

Primordial germ cells identified as one potential cell of origin of MYC rhabdoid tumors

Project description:Primordial germ cells identified as one potential cell of origin of MYC rhabdoid tumors

| PRJNA779861 | ENA

Primordial germ cells identified as one potential cell of origin of MYC rhabdoid tumors

Project description:Primordial germ cells identified as one potential cell of origin of MYC rhabdoid tumors

| PRJNA780462 | ENA

Primordial germ cells identified as one potential cell of origin of MYC rhabdoid tumors

Project description:Primordial germ cells identified as one potential cell of origin of MYC rhabdoid tumors

| PRJNA780463 | ENA

Single-cell transcriptomics identifies potential cells of origin of MYC rhabdoid tumors.

Project description:Rhabdoid tumors (RT) are rare and highly aggressive pediatric neoplasms. Their epigenetically-driven intertumoral heterogeneity is well described; however, the cellular origin of RT remains an enigma. Here, we establish and characterize different genetically engineered mouse models driven under the control of distinct promoters and being active in early progenitor cell types with diverse embryonic onsets. From all models only Sox2-positive progenitor cells give rise to murine RT. Using single-cell analyses, we identify distinct cells of origin for the SHH and MYC subgroups of RT, rooting in early stages of embryogenesis. Intra- and extracranial MYC tumors harbor common genetic programs and potentially originate from fetal primordial germ cells (PGCs). Using PGC specific Smarcb1 knockout mouse models we validate that MYC RT originate from these progenitor cells. We uncover an epigenetic imbalance in MYC tumors compared to PGCs being sustained by epigenetically-driven subpopulations. Importantly, treatments with the DNA demethylating agent decitabine successfully impair tumor growth in vitro and in vivo. In summary, our work sheds light on the origin of RT and supports the clinical relevance of DNA methyltransferase inhibitors against this disease.

| S-EPMC8941154 | biostudies-literature

Genome-wide methylation profiles in primary intracranial germ cell tumors indicate primordial germ cell origin of germinoma

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2016-04-01 | E-GEOD-70787 | biostudies-arrayexpress

Genome-wide methylation profiles in primary intracranial germ cell tumors indicate primordial germ cell origin of germinoma

Project description:This SuperSeries is composed of the SubSeries listed below.

2016-04-01 | GSE70787 | GEO