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Cortical miR-709 links glutamatergic signaling to NREM sleep EEG slow waves in an activity-dependent manner [NanoString]

ABSTRACT: Micro-RNAs (miRNAs) are key, post-transcriptional regulators of gene expression that have been implicated in a plethora of biological processes. Their role in sleep, however, has received little attention. In this experiment, we investigated the effects of in vivo miR-709 inhibition on the cortical transcriptome of adult mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE189313 | GEO | 2024/01/12

REPOSITORIES: GEO

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Cortical miR-709 links glutamatergic signaling to NREM sleep EEG slow waves in an activity-dependent manner [agilent_forebrain]

Project description:Micro-RNAs (miRNAs) are key, post-transcriptional regulators of gene expression that have been implicated in a plethora of biological processes. Their role in sleep, however, has received little attention. We first investigated the effects of sleep deprivation on the brain miRNA transcriptome. Sleep deprivation affected 52 miRNAs in the whole brain, and particularly miR-709, an activity-dependent microRNA, enriched in the cerebral cortex.

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Cortical miR-709 links glutamatergic signaling to NREM sleep EEG slow waves in an activity-dependent manner [RNA-seq]

Project description:Micro-RNAs (miRNAs) are key, post-transcriptional regulators of gene expression that have been implicated in a plethora of biological processes. Their role in sleep, however, has received little attention. In the current experiment, we investigated the effects of in vitro miR-709 inhibition on the transcriptome of primary cortical neurons.

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Cortical miR-709 links glutamatergic signaling to NREM sleep EEG slow waves in an activity-dependent manner [agilent_cortex_hippocampus]

Project description:Micro-RNAs (miRNAs) are key, post-transcriptional regulators of gene expression that have been implicated in a plethora of biological processes. Their role in sleep, however, has received little attention. In this experiment we investigated the effects of sleep deprivation on the cortex and hippocampus miRNA transcriptome. In this experiment we observed different miRNAs being affected by sleep deprivation in the cortex and hippocampus.

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Cortical miR-709 links glutamatergic signaling to NREM sleep EEG slow waves in an activity-dependent manner

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-01-12 | GSE189353 | GEO

Cortical miR-709 links glutamatergic signaling to NREM sleep EEG slow waves in an activity-dependent manner [NanoString]

Project description:Cortical miR-709 links glutamatergic signaling to NREM sleep EEG slow waves in an activity-dependent manner [NanoString]

| PRJNA782534 | ENA

Cortical miR-709 links glutamatergic signaling to NREM sleep EEG slow waves in an activity-dependent manner

Project description:Cortical miR-709 links glutamatergic signaling to NREM sleep EEG slow waves in an activity-dependent manner

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Cortical miR-709 links glutamatergic signaling to NREM sleep EEG slow waves in an activity-dependent manner [agilent_cortex_hippocampus]

Project description:Cortical miR-709 links glutamatergic signaling to NREM sleep EEG slow waves in an activity-dependent manner [agilent_cortex_hippocampus]

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Cortical miR-709 links glutamatergic signaling to NREM sleep EEG slow waves in an activity-dependent manner [agilent_forebrain]

Project description:Cortical miR-709 links glutamatergic signaling to NREM sleep EEG slow waves in an activity-dependent manner [agilent_forebrain]

| PRJNA782634 | ENA

Cortical miR-709 links glutamatergic signaling to NREM sleep EEG slow waves in an activity-dependent manner [RNA-seq]

Project description:Cortical miR-709 links glutamatergic signaling to NREM sleep EEG slow waves in an activity-dependent manner [RNA-seq]

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Local and Widespread Slow Waves in Stable NREM Sleep: Evidence for Distinct Regulation Mechanisms.

Project description:Previous work showed that two types of slow waves are temporally dissociated during the transition to sleep: widespread, large and steep slow waves predominate early in the falling asleep period (type I), while smaller, more circumscribed slow waves become more prevalent later (type II). Here, we studied the possible occurrence of these two types of slow waves in stable non-REM (NREM) sleep and explored potential differences in their regulation. A heuristic approach based on slow wave synchronization efficiency was developed and applied to high-density electroencephalographic (EEG) recordings collected during consolidated NREM sleep to identify the potential type I and type II slow waves. Slow waves with characteristics compatible with those previously described for type I and type II were identified in stable NREM sleep. Importantly, these slow waves underwent opposite changes across the night, with only type II slow waves displaying a clear homeostatic regulation. In addition, we showed that the occurrence of type I slow waves was often followed by larger type II slow waves, whereas the occurrence of type II slow waves was usually followed by smaller type I waves. Finally, type II slow waves were associated with a relative increase in spindle activity, while type I slow waves triggered periods of high-frequency activity. Our results provide evidence for the existence of two distinct slow wave synchronization processes that underlie two different types of slow waves. These slow waves may have different functional roles and mark partially distinct "micro-states" of the sleeping brain.

| S-EPMC6018150 | biostudies-literature

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