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Cortical miR-709 links glutamatergic signaling to NREM sleep EEG slow waves in an activity-dependent manner [agilent_cortex_hippocampus]

ABSTRACT: Cortical miR-709 links glutamatergic signaling to NREM sleep EEG slow waves in an activity-dependent manner [agilent_cortex_hippocampus]

PROVIDER: PRJNA782549 | ENA |

REPOSITORIES: ENA

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Cortical miR-709 links glutamatergic signaling to NREM sleep EEG slow waves in an activity-dependent manner

Project description:Cortical miR-709 links glutamatergic signaling to NREM sleep EEG slow waves in an activity-dependent manner

| PRJNA782625 | ENA

Cortical miR-709 links glutamatergic signaling to NREM sleep EEG slow waves in an activity-dependent manner [agilent_forebrain]

Project description:Cortical miR-709 links glutamatergic signaling to NREM sleep EEG slow waves in an activity-dependent manner [agilent_forebrain]

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Cortical miR-709 links glutamatergic signaling to NREM sleep EEG slow waves in an activity-dependent manner [NanoString]

Project description:Cortical miR-709 links glutamatergic signaling to NREM sleep EEG slow waves in an activity-dependent manner [NanoString]

| PRJNA782534 | ENA

Cortical miR-709 links glutamatergic signaling to NREM sleep EEG slow waves in an activity-dependent manner [RNA-seq]

Project description:Cortical miR-709 links glutamatergic signaling to NREM sleep EEG slow waves in an activity-dependent manner [RNA-seq]

| PRJNA782602 | ENA

Cortical miR-709 links glutamatergic signaling to NREM sleep EEG slow waves in an activity-dependent manner [NanoString]

Project description:Micro-RNAs (miRNAs) are key, post-transcriptional regulators of gene expression that have been implicated in a plethora of biological processes. Their role in sleep, however, has received little attention. In this experiment, we investigated the effects of in vivo miR-709 inhibition on the cortical transcriptome of adult mice.

2024-01-12 | GSE189313 | GEO

Cortical miR-709 links glutamatergic signaling to NREM sleep EEG slow waves in an activity-dependent manner [agilent_forebrain]

Project description:Micro-RNAs (miRNAs) are key, post-transcriptional regulators of gene expression that have been implicated in a plethora of biological processes. Their role in sleep, however, has received little attention. We first investigated the effects of sleep deprivation on the brain miRNA transcriptome. Sleep deprivation affected 52 miRNAs in the whole brain, and particularly miR-709, an activity-dependent microRNA, enriched in the cerebral cortex.

2024-01-12 | GSE189348 | GEO

Cortical miR-709 links glutamatergic signaling to NREM sleep EEG slow waves in an activity-dependent manner [RNA-seq]

Project description:Micro-RNAs (miRNAs) are key, post-transcriptional regulators of gene expression that have been implicated in a plethora of biological processes. Their role in sleep, however, has received little attention. In the current experiment, we investigated the effects of in vitro miR-709 inhibition on the transcriptome of primary cortical neurons.

2024-01-12 | GSE189335 | GEO

Cortical miR-709 links glutamatergic signaling to NREM sleep EEG slow waves in an activity-dependent manner

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-01-12 | GSE189353 | GEO

Cortical miR-709 links glutamatergic signaling to NREM sleep EEG slow waves in an activity-dependent manner [agilent_cortex_hippocampus]

Project description:Micro-RNAs (miRNAs) are key, post-transcriptional regulators of gene expression that have been implicated in a plethora of biological processes. Their role in sleep, however, has received little attention. In this experiment we investigated the effects of sleep deprivation on the cortex and hippocampus miRNA transcriptome. In this experiment we observed different miRNAs being affected by sleep deprivation in the cortex and hippocampus.

2024-01-12 | GSE189319 | GEO

mmu-miR-709 gene targets

Project description:We analyzed miRNA profiles in normal liver and identified miR-709, a highly abundant miRNA in this tissue. Through microarray analysis, gene targets were identified. Thirty-six genes were significantly down-regulated >2-fold in the miR-709-treated relative to the control group, and at least three of them, including Ras-related protein 11b (Rab11b), phosphatidylcholine transfer protein (Pctp), and carboxylesterase 1g (Ces1g), are direct targets. miR-709 regulates genes implicated in cytoskeleton organization, extracellular matrix attachment, cell proliferation and fatty acid metabolism, suggesting a coordinated response during cell division, when cytoskeleton remodeling requires substantial changes in gene expression.

2015-09-30 | GSE63875 | GEO

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