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Tissue-specific imprinting and heterogeneity of natural killer cells and group 1 innate lymphoid cells

ABSTRACT: We report here the identification, by CITE-seq and scRNA-seq, of distinct NK cells, ILC1s and intermediate subsets across 4 tissues at steady state. We found that unlike NK cells, which had a signature well conserved between organs, ILC1s exhibited a great heterogeneity depending on the tissue microenvironment, at both the phenotypic and transcriptomic levels. Finally, we performed a multidimensional comparison of these cells across tissues and identified sets of genes expressed by each related subsets.

ORGANISM(S): Mus musculus

PROVIDER: GSE189807 | GEO | 2022/11/16

REPOSITORIES: GEO

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scRNAseq of human blood, tonsil, lung and small intestine innate lymphoid cells

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scRNASeq of human innate lymphoid cells from different compartments

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Hematopoietic cell-derived IL-15 is essential for group 1 innate lymphoid cell (ILC) development in the bone marrow

Project description:This study reveals the role of IL-15 produced by hematopoeitic cells in the development of NK cells and ILC type 1 cells (ILC1s) in the bone marrow.

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