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Single-cell RNA sequencing on the testis from the rete testis-specific Sox17 conditioinal knockout (cKO) mice and the controls at P14.

ABSTRACT: In mammalian testes, a valve-like structure called Sertoli valve is located at the border region of the seminiferous tubule and the rete testis. Having identified Sox17 in the rete testis as a positive regulator of the valve formation, this study aim to elucidate the mechanism of Sox17-expressing rete testis to modulate the testicular homeostasis. Our scRNA-seq data demonstrate the altered gene expression levels of several growth factors in Sox17-depleted rate testis epithelia, and highlighted the altered proportion of Sertoli cells located around the proximal part of the testis. This study provides a comprehensive profile of the proximal part of the testis including the rete testis and Sertoli valve for the first time, and further illustrate the functional role of the Sox17+ rete tesits to orchestrate the testicular homeostasis.

ORGANISM(S): Mus musculus

PROVIDER: GSE190043 | GEO | 2022/11/27

REPOSITORIES: GEO

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