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Interleukin-10/CSF1R fusion protein rejuvenates the exhausted T cells for executing antitumor activity

ABSTRACT: Single cell sequence (SC-seq) has been used to explore the effect of IL10/CSF1R fusion protein modulation in tumor microenvironment. Four groups were analyzed which contain Ctrl, CSF1R, IL10 and BF10. MTC-Q1 oral cancer cells were orthotopic injection in C57BL/6 mice. CD45+ immune cells has been isolated, analyzed and sequenced by dropped based scRNA-seq, cDNA were sequenced by Illumina Novaseq 6000.

ORGANISM(S): Mus musculus

PROVIDER: GSE190111 | GEO | 2023/07/09

REPOSITORIES: GEO

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