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Interleukin-10/CSF1R fusion protein rejuvenates the exhausted T cells for executing antitumor activity V

ABSTRACT: Interleukin-10/CSF1R fusion protein rejuvenates the exhausted T cells for executing antitumor activity V

PROVIDER: PRJNA794196 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR17433002.fastq.gz	Fastqsanger.gz
	SRR17433003.fastq.gz	Fastqsanger.gz
	SRR17433004.fastq.gz	Fastqsanger.gz
	SRR17433005.fastq.gz	Fastqsanger.gz
	SRR17433006.fastq.gz	Fastqsanger.gz

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Interleukin-10/CSF1R fusion protein rejuvenates the exhausted T cells for executing antitumor activity

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Interleukin-10/CSF1R fusion protein rejuvenates the exhausted T cells for executing antitumor activity III

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Interleukin-10/CSF1R fusion protein rejuvenates the exhausted T cells for executing antitumor activity II

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Interleukin-10/CSF1R fusion protein rejuvenates the exhausted T cells for executing antitumor activity IV

Project description:Interleukin-10/CSF1R fusion protein rejuvenates the exhausted T cells for executing antitumor activity IV

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Interleukin-10/CSF1R fusion protein rejuvenates the exhausted T cells for executing antitumor activity

Project description:Single cell sequence (SC-seq) has been used to explore the effect of IL10/CSF1R fusion protein modulation in tumor microenvironment. Four groups were analyzed which contain Ctrl, CSF1R, IL10 and BF10. MTC-Q1 oral cancer cells were orthotopic injection in C57BL/6 mice. CD45+ immune cells has been isolated, analyzed and sequenced by dropped based scRNA-seq, cDNA were sequenced by Illumina Novaseq 6000.

2023-07-09 | GSE190111 | GEO

Interleukin-10/CSF1R fusion protein rejuvenates the exhausted T cells for executing antitumor activity V

Project description:Bulk RNA sequence (RNA-seq) has been used to explore the effect of IL10/CSF1R fusion protein modulation in tumor microenvironment. Four groups were analyzed which contain Ctrl, CSF1R, IL10 and BF10. MTC-Q1 oral cancer cells were orthotopic injection into C57BL/6J mice. tumor tissue has been isolated (~ 100 mm3) and total RNA were extracted by Trizol, followed by cDNA were sequenced by Illumina NextSeq 550.

2023-07-09 | GSE193054 | GEO

Interleukin-10/CSF1R fusion protein rejuvenates the exhausted T cells for executing antitumor activity IV

2023-07-09 | GSE193051 | GEO

Interleukin-10/CSF1R fusion protein rejuvenates the exhausted T cells for executing antitumor activity III

Project description:Bulk RNA sequence (RNA-seq) has been used to explore the effect of IL10/CSF1R fusion protein modulation in tumor microenvironment. Four groups were analyzed which contain Ctrl, CSF1R, IL10 and BF10. MTC-Q1 oral cancer cells were orthotopic injection in C57BL/6 mice. CD45-negatve cells has been isolated and RNA were extracted by Trizol, followed by cDNA were sequenced by Illumina NextSeq 550.

2023-07-09 | GSE193050 | GEO

Interleukin-10/CSF1R fusion protein rejuvenates the exhausted T cells for executing antitumor activity II

Project description:Bulk RNA sequence (RNA-seq) has been used to explore the effect of IL10/CSF1R fusion protein modulation in tumor microenvironment. Four groups were analyzed which contain Ctrl, CSF1R, IL10 and BF10. 4T1 breast cancer cells were orthotopic injection into Balb/c mice. tumor tissue has been isolated (~ 100 mm3) and total RNA were extracted by Trizol, followed by cDNA were sequenced by Illumina NextSeq 550.

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Project description:Fresh human breast tumor tissue was dissociated into single cells and viably frozen. Patient samples were annotated as having an ""exhausted"" or ""non-exhausted"" immune environment based on CyTOF characterization of T cell phenotypes (Wagner et al, Cell 2019). 14 samples (7 exhausted, 7 non-exhausted) were selected for scRNA-seq (without prior cell type enrichment) with the goal to compare the two immune environment types and to comprehensively characterize exhaustion-associated features of the tumor microenvironment.

2023-08-25 | E-MTAB-10607 | biostudies-arrayexpress

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