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Expression data of miRNAs and lncRNAs from the lumbosacral spinal cord of fetal rats with anorectal malformations in embryonic day 19

ABSTRACT: many dysregulated miRNAs and lncRNAs as the primary factor could be play an important role in the development of lumbosacral spinal cord of fetal rats with anorectal malformations in embryonic day 17.High-throughput sequencing was utilized to reveal the expression of non-coding RNAs underlying the development of anorectal malformations.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE190332 | GEO | 2024/11/29

REPOSITORIES: GEO

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Expression data of miRNAs and lncRNAs from the lumbosacral spinal cord of fetal rats with anorectal malformations in embryonic day 17

Project description:Many dysregulated miRNAs and lncRNAs as the primary factor could be play an important role in the development of lumbosacral spinal cord of fetal rats with anorectal malformations in embryonic day 17. High-throughput sequencing was utilized to reveal the expression of non-coding RNAs underlying the development of anorectal malformations.

2024-11-29 | GSE190331 | GEO

Expression data of miRNAs and lncRNAs from the lumbosacral spinal cord of fetal rats with anorectal malformations in embryonic day 19

Project description:Expression data of miRNAs and lncRNAs from the lumbosacral spinal cord of fetal rats with anorectal malformations in embryonic day 19

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Expression data of miRNAs and mRNAs from the fetal rats with anorectal malformations

Project description:many dysregulated mRNAs as the primary factor could be play an important role in the development of anorectum we used microarrays to reveal the global programme of gene expression underlying the development of anorectal malformations.

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Expression data of miRNAs and lncRNAs from the lumbosacral spinal cord of fetal rats with anorectal malformations in embryonic days 17 and 19

Project description:Expression data of miRNAs and lncRNAs from the lumbosacral spinal cord of fetal rats with anorectal malformations in embryonic days 17 and 19

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Expression data of miRNAs and lncRNAs from the lumbosacral spinal cord of fetal rats with anorectal malformations in embryonic day 17

Project description:Expression data of miRNAs and lncRNAs from the lumbosacral spinal cord of fetal rats with anorectal malformations in embryonic day 17

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Expression data of circRNAs from the fetal rats with anorectal malformations

Project description:Anorectal malformations (ARMs) are among the most common congenital terminal digestive tract malformations. Circular RNAs (circRNAs), a novel type of endogenous non-coding RNAs, play roles in the development of the digestive system; however, their contributions to the pathogenesis of ARMs are not well-established. Many dysregulated circRNAs as the primary factor could play an important role in the development of anorectum. We used high-throughput sequencing to reveal the regulatory mechanism of gene expression underlying the development of anorectal malformations. These results provide original insight into the roles of circRNAs in ARMs and provide a valuable resource for further analyses of molecular mechanisms and signaling networks.

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Expression data of miRNAs and lncRNAs from the lumbosacral spinal cord of fetal rats with anorectal malformations in embryonic days 17 and 19

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-11-29 | GSE190333 | GEO

Expression data of miRNAs and mRNAs from the fetal rats with anorectal malformations

Project description:Expression data of miRNAs and mRNAs from the fetal rats with anorectal malformations

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Expression data of circRNAs from the fetal rats with anorectal malformations

Project description:Expression data of circRNAs from the fetal rats with anorectal malformations

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Quantitive protein profiling and pathway analysis for spinal arteriovenous malformations

Project description:Spinal arteriovenous malformations (sAVM) were rare and heterogeneous group of blood vessel disorders that affected the function of spinal cord directly or indirectly. In the past decades, the pathogenesis for SAVM was still not elucidated. Here we compared the specimens of four sAVM obtained from surgery and control samples from donations using TMT labeled proteomic study. In our proteomic study, we identified a total of 3101 proteins and 654-proteins were changed in SAVM compares with control, among which 96 proteins were upregulated and 358 proteins were downregulated. Gene Ontology (GO) analysis revealed that extracellular matrix organization in biological process and integrin binding proteins in molecular function were the most enriched items. Four significant changed proteins (PLG, MPZ, MMP9 and RPL23a) were verified by Western blot. The pathway analysis revealed that the changed proteins in pathways of angiogenesis, focal adhesion and cytoplasmic ribosome likely contributed to SAVM. The protein profile changes identified by our proteomic studies provide a comprehensive understanding of sAVM for us.

2018-06-18 | PXD007982 | Pride

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