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Expression data of miRNAs and lncRNAs from the lumbosacral spinal cord of fetal rats with anorectal malformations in embryonic days 17 and 19

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE190333 | GEO | 2024/11/29

REPOSITORIES: GEO

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Expression data of miRNAs and lncRNAs from the lumbosacral spinal cord of fetal rats with anorectal malformations in embryonic day 17

Project description:Many dysregulated miRNAs and lncRNAs as the primary factor could be play an important role in the development of lumbosacral spinal cord of fetal rats with anorectal malformations in embryonic day 17. High-throughput sequencing was utilized to reveal the expression of non-coding RNAs underlying the development of anorectal malformations.

2024-11-29 | GSE190331 | GEO

Expression data of miRNAs and lncRNAs from the lumbosacral spinal cord of fetal rats with anorectal malformations in embryonic day 19

Project description:many dysregulated miRNAs and lncRNAs as the primary factor could be play an important role in the development of lumbosacral spinal cord of fetal rats with anorectal malformations in embryonic day 17.High-throughput sequencing was utilized to reveal the expression of non-coding RNAs underlying the development of anorectal malformations.

2024-11-29 | GSE190332 | GEO

Expression data of miRNAs and lncRNAs from the lumbosacral spinal cord of fetal rats with anorectal malformations in embryonic days 17 and 19

Project description:Expression data of miRNAs and lncRNAs from the lumbosacral spinal cord of fetal rats with anorectal malformations in embryonic days 17 and 19

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Expression data of miRNAs and lncRNAs from the lumbosacral spinal cord of fetal rats with anorectal malformations in embryonic day 17

Project description:Expression data of miRNAs and lncRNAs from the lumbosacral spinal cord of fetal rats with anorectal malformations in embryonic day 17

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Expression data of miRNAs and lncRNAs from the lumbosacral spinal cord of fetal rats with anorectal malformations in embryonic day 19

Project description:Expression data of miRNAs and lncRNAs from the lumbosacral spinal cord of fetal rats with anorectal malformations in embryonic day 19

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Expression data of miRNAs and mRNAs from the fetal rats with anorectal malformations

Project description:many dysregulated mRNAs as the primary factor could be play an important role in the development of anorectum we used microarrays to reveal the global programme of gene expression underlying the development of anorectal malformations.

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Expression data of circRNAs from the fetal rats with anorectal malformations

Project description:Anorectal malformations (ARMs) are among the most common congenital terminal digestive tract malformations. Circular RNAs (circRNAs), a novel type of endogenous non-coding RNAs, play roles in the development of the digestive system; however, their contributions to the pathogenesis of ARMs are not well-established. Many dysregulated circRNAs as the primary factor could play an important role in the development of anorectum. We used high-throughput sequencing to reveal the regulatory mechanism of gene expression underlying the development of anorectal malformations. These results provide original insight into the roles of circRNAs in ARMs and provide a valuable resource for further analyses of molecular mechanisms and signaling networks.

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Conservative and Surgical Management of Spinal Cord Cavernous Malformations.

Project description:Objectives:We present a case series of spinal cord cavernous malformations (SCCMs) to describe clinical presentation and outcomes of both surgical and conservative management. Methods:The clinical courses of patients diagnosed with SCCMs at our institution were retrospectively reviewed. Neurologic symptoms were evaluated using the Modified McCormick Scale. Results:A total of 18 patients were identified. Five patients (27.8%) presented with acute onset bleeding, 4 of whom underwent immediate surgical resection. Thirteen patients (72.2%) were initially managed conservatively. Eight patients (38.9%) developed a hemorrhage during follow-up, and 8 (38.9%) required surgical resection due to bleeding or neurological worsening. The mean (range) duration from primary symptoms to subsequent hemorrhage or deterioration of symptoms was 1.42 (range: 0.25-4.33) years. The mean duration from primary symptoms to surgery was 2.10 (range: 0.25-5.0) years. No patients experienced subsequent hemorrhage after surgical resection. Eleven patients (84.6%) in the surgery group showed improved neurological status, and 2 patients (15.4%) remained unchanged. The annualized subsequent hemorrhage risk was 3.7%. Patients in the immediate surgical group had a significantly larger lesion compared with those in the conservative group. There was significance between the worst Modified McCormick Scale grades at the time of debilitating symptoms and the length of hemorrhage, but not the size of the lesion. Conclusions:Surgery for SCCMs resulted in no recurrence of hemorrhage or exacerbation of neurological symptoms, and should be considered for patients who experienced acute onset of hemorrhage or debilitating symptoms during follow-up.

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Ectopic expression of Ptf1a induces spinal defects, urogenital defects, and anorectal malformations in Danforth's short tail mice.

Project description:Danforth's short tail (Sd) is a semidominant mutation on mouse chromosome 2, characterized by spinal defects, urogenital defects, and anorectal malformations. However, the gene responsible for the Sd phenotype was unknown. In this study, we identified the molecular basis of the Sd mutation. By positional cloning, we identified the insertion of an early transposon in the Sd candidate locus approximately 12-kb upstream of Ptf1a. We found that insertion of the transposon caused overexpression of three neighboring genes, Gm13344, Gm13336, and Ptf1a, in Sd mutant embryos and that the Sd phenotype was not caused by disruption of an as-yet-unknown gene in the candidate locus. Using multiple knockout and knock-in mouse models, we demonstrated that misexpression of Ptf1a, but not of Gm13344 or Gm13336, in the notochord, hindgut, cloaca, and mesonephros was sufficient to replicate the Sd phenotype. The ectopic expression of Ptf1a in the caudal embryo resulted in attenuated expression of Cdx2 and its downstream target genes T, Wnt3a, and Cyp26a1; we conclude that this is the molecular basis of the Sd phenotype. Analysis of Sd mutant mice will provide insight into the development of the spinal column, anus, and kidney.

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Expression data of miRNAs and mRNAs from the fetal rats with anorectal malformations

Project description:Expression data of miRNAs and mRNAs from the fetal rats with anorectal malformations

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