CACYBP is required for epidermal homeostasis
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ABSTRACT: RNA-seq was used to define the role of CACYBP in epidermal differentiation by first employing CRISPR/Cas9 to disrupt CACYBP with two independent single guide RNAs (sgRNAs) to create pools of CACYBP-ablated primary human keratinocytes that were immortalized with HPV E6/E7 and then placed onto human dermis and grown for three days at the air-liquid interface to generate organotypic skin tissue.
ORGANISM(S): Homo sapiens
PROVIDER: GSE190864 | GEO | 2022/06/24
REPOSITORIES: GEO
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