Transcriptomics

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MAB21L4 is required for epidermal homeostasis


ABSTRACT: RNA-seq was used to define the role of MAB21L4 in epidermal differentiation by first employing CRISPR/Cas9 to disrupt MAB21L4 with two independent single guide RNAs (sgRNAs) to create pools of MAB21L4-ablated primary human keratinocytes that were then placed onto human dermis and grown for three days at the air-liquid interface to generate organotypic skin tissue.

ORGANISM(S): Homo sapiens

PROVIDER: GSE190866 | GEO | 2022/06/24

REPOSITORIES: GEO

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