Expression data from human umbilical vein endothelial cells (HUVECs) as a function of cell adhesion and VEGF exposure
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ABSTRACT: Angiogenesis is tightly regulated by both soluble growth factors and cellular interactions with the extracellular matrix (ECM). While cell adhesion via integrins has been shown to be required for growth factor signaling and downstream angiogenesis, the effects of quantitative changes in cell adhesion and spreading against the ECM remain less clear. Examining changes in global gene expression in limited versus high adhesion contexts in human umbilical vein endothelial cells, we demonstrated a VEGF-induced upregulation of genes associated with vascular invasion and remodeling when cell adhesion was restricted, whereas cells on highly adhesive surfaces upregulated genes associated with a proliferative response.
ORGANISM(S): Homo sapiens
PROVIDER: GSE19098 | GEO | 2010/12/15
SECONDARY ACCESSION(S): PRJNA120523
REPOSITORIES: GEO
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