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Global genomic and proteomic analysis of TNBC cells identifies the critical role of PELP1 in ribosome biogenesis

ABSTRACT: We examined the mechanisms by which PELP1 regulates TNBC progression. MDA-MB-231 cells were stably transfected with control non-targeted shRNA or PELP1 shRNA, and total RNA was isolated for RNA-seq analysis. Our results demonstrated that PELP1 regulates the expression of Myc, E2F and mTOR targets in TNBC.

ORGANISM(S): Homo sapiens

PROVIDER: GSE191066 | GEO | 2022/03/03

REPOSITORIES: GEO

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