Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Hung-I Chen
PROVIDER: E-GEOD-72136 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Sareddy Gangadhara R GR Zhang Quanguang Q Wang Ruimin R Scott Erin E Zou Yi Y O'Connor Jason C JC Chen Yidong Y Dong Yan Y Vadlamudi Ratna K RK Brann Darrell D
Proceedings of the National Academy of Sciences of the United States of America 20151116 48
17-β estradiol (E2) has been implicated as neuroprotective in a variety of neurodegenerative disorders. However, the underlying mechanism remains unknown. Here, we provide genetic evidence, using forebrain-specific knockout (FBKO) mice, that proline-, glutamic acid-, and leucine-rich protein 1 (PELP1), an estrogen receptor coregulator protein, is essential for the extranuclear signaling and neuroprotective actions of E2 in the hippocampal CA1 region after global cerebral ischemia (GCI). E2-media ...[more]