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Transcriptomic profiling of NASH in guinea pigs fed a high or low fat diet with either high or low vitamin C content

ABSTRACT: This study investigated the effect of vitamin C deficiency combined with/without a change to a low fat diet on the NAFLD/NASH hepatic transcriptome in the guinea pig NASH model. Vitamin C deficiency per se did not accelerate disease induction. However, the results showed a clear effect of the diet change on resolution of hepatic hallmarks (p<0.05), and indicated a positive effect of a high vitamin C intake compared to both high fat groups. The data suggest that a poor vitamin C status delays the reversion towards a healthy hepatic transcriptome and phenotype. In conclusion, the findings support a beneficial role of adequate vitamin C intake in the regression of NASH and may indicate that vitamin C supplementation in addition to lifestyle modifications could accelerate recovery in NASH patients with poor vitamin C status.

ORGANISM(S): Cavia porcellus

PROVIDER: GSE192497 | GEO | 2022/01/26

REPOSITORIES: GEO

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Hepatic transcriptome profiles of mice with diet-induced nonalcoholic steatohepatitis treated with astaxanthin and vitamin E

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