Transcriptomic analysis of synovial cells derived from collagen-induced arthritis mice
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ABSTRACT: The destruction of bone and cartilage results in a loss of joint functionality, critically impairing the quality of life in arthritis patients. Synovial fibroblasts (SFs) critically contribute to the pathogenesis of rheumatoid arthritis (RA) by acquiring either a pro-inflammatory or tissue-destructive phenotype. To explore the molecular mechanisms underlying the pathogenic fibroblast phenotype in arthritis, we performed single-cell RNA sequencing (scRNA-seq) on the synovial cells which were isolated from collagen-induced arthritis (CIA) mice.
ORGANISM(S): Mus musculus
PROVIDER: GSE192504 | GEO | 2022/07/06
REPOSITORIES: GEO
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