Proteomics

Dataset Information

0

The role of extracellular vesicles in synovial fibroblast senescence


ABSTRACT: In arthritis, synovial fibroblast (SF) senescence is linked to the activation of a pro-inflammatory phenotype contributing to chronic arthritis pathogenesis. Additionally, senescent cells accumulate in ageing tissues further promoting ageing and inflammation. These cells have dysregulated mitochondrial function and metabolism, limited tissue regeneration, produce reactive oxygen species (ROS) and secrete bioactive molecules, including pro-inflammatory cytokines, chemokines and matrix-remodelling enzymes known as SASP (senescence-associated secretory phenotype). In vitro, senescent cells can induce a senescent phenotype in surrounding bystander cells. Interestingly, extracellular vesicles (EVs) have critical roles in cellular senescence and ageing and are mediators in intercellular communication. We hypothesize that senescent cells in osteoarthritic SFs induce senescence and/or a proinflammatory phenotype in non-senescent osteoarthritic SFs, mediated through EV cargo.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

SUBMITTER: James Anderson  

LAB HEAD: Mandy Jayne Peffers

PROVIDER: PXD032757 | Pride | 2022-10-15

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
1_Control.mgf Mgf
1_Control.mzid.gz Mzid
1_Control.raw Raw
1_Xray.mgf Mgf
1_Xray.mzid.gz Mzid
Items per page:
1 - 5 of 42
altmetric image

Publications


Extracellular vesicles are mediators of intercellular communication with critical roles in cellular senescence and ageing. In arthritis, senescence is linked to the activation of a pro-inflammatory phenotype contributing to chronic arthritis pathogenesis. We hypothesised that senescent osteoarthritic synovial fibroblasts induce senescence and a pro-inflammatory phenotype in non-senescent osteoarthritic fibroblasts, mediated through extracellular vesicle cargo. Small RNA-sequencing and mass spect  ...[more]

Similar Datasets

2024-06-16 | PXD046001 | Pride
2023-05-25 | GSE204828 | GEO
2022-02-17 | PXD027232 | Pride
2023-04-30 | GSE200157 | GEO
2022-02-16 | PXD028772 | Pride
2023-09-07 | PXD037373 | Pride
2018-10-25 | PXD003018 | Pride
2022-06-27 | GSE160503 | GEO
2024-03-15 | MSV000094326 | GNPS
2022-11-15 | MTBLS4568 | MetaboLights