Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
SUBMITTER: James Anderson
LAB HEAD: Mandy Jayne Peffers
PROVIDER: PXD032757 | Pride | 2022-10-15
REPOSITORIES: Pride
Action | DRS | |||
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1_Control.mgf | Mgf | |||
1_Control.mzid.gz | Mzid | |||
1_Control.raw | Raw | |||
1_Xray.mgf | Mgf | |||
1_Xray.mzid.gz | Mzid |
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Wijesinghe Susanne N SN Anderson James J Brown Thomas J TJ Nanus Dominika E DE Housmans Bas B Green Jonathan A JA Hackl Matthias M Choi Katie K KK Arkill Kenton P KP Welting Tim T James Victoria V Jones Simon W SW Peffers Mandy J MJ
Frontiers in molecular biosciences 20220923
Extracellular vesicles are mediators of intercellular communication with critical roles in cellular senescence and ageing. In arthritis, senescence is linked to the activation of a pro-inflammatory phenotype contributing to chronic arthritis pathogenesis. We hypothesised that senescent osteoarthritic synovial fibroblasts induce senescence and a pro-inflammatory phenotype in non-senescent osteoarthritic fibroblasts, mediated through extracellular vesicle cargo. Small RNA-sequencing and mass spect ...[more]