EZH2 inhibition in glioblastoma stem cells is associated with increased expression of neuronal genes and the neuronal developmental regulators ZIC2, ZNF423 and MAFB
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ABSTRACT: Here we use two GBM stem cell lines, representing the classical/pro-neural and mesenchymal GBM subtypes, to investigate the effects of three different EZH2 inhibitors on GBM stem cell survival and gene expression: EPZ6438, GSK343 and UNC1999. RNA-seq analysis revealed that all three EZH2 inhibitors led to increased expression of genes related to neurogenesis and/or neuronal structure in both GBM stem cell lines. Chromatin immunoprecipitation (ChIP-Seq) was used to identify potential direct targets of the histone methylation activity of EZH2 that might be driving the increase in neuronal gene expression.
ORGANISM(S): Homo sapiens
PROVIDER: GSE192710 | GEO | 2022/09/01
REPOSITORIES: GEO
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