LATS1 is a Central Signal Transmitter for Achieving Full Type-I Interferon Activity [2fTGH cells]
Ontology highlight
ABSTRACT: Interferons (IFNs) possess broad-spectrum antiviral activity to resist virus epidemic. However, IFNs antiviral efficacy needs to be greatly improved. Here, we reveal that LATS1 is a vital signal transmitter governing full type-I-interferon (IFN-I) signaling activity. Importantly, LATS1 deficiency restricts IFN-I signaling and attenuates host antiviral immune response.
ORGANISM(S): Homo sapiens
PROVIDER: GSE193088 | GEO | 2022/04/13
REPOSITORIES: GEO
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