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Idronoxil inhibition of TBK1 signalling

ABSTRACT: Purpose: Analysis of the transcriptional effects of Idronoxil (IDX) on primary bone marrow derived macrophages (BMDMs) from Trex1 mutant mice. Methods: Primary BMDMs from 3 different mice were treated overnight with Idronoxil at 1.25uM. RNA sequencing was performed with one NextSeq2000 P2 run using 19bp forward read and 101bp reverse reads. Conclusion: Idronoxil strongly decreased the basal TBK1 driven interferon gene signature in these cells.

ORGANISM(S): Mus musculus

PROVIDER: GSE193353 | GEO | 2023/08/08

REPOSITORIES: GEO

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A bioactive mammalian disaccharide associated with autoimmunity activates a STING-TBK1-dependent immune response

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