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A comprehensive immune cell atlas of cystic kidney disease reveals the involvement of adaptive immune cells in injury mediated cyst progression

ABSTRACT: It is widely accepted that injuries to cilia mutant mice accelerate the rate of cystic kidney disease; however, cellular factors that drive the accelerated rate of cystic disease are unknown. By performing single cell RNA sequencing of all CD45+ immune cells, we find that the subtype and gene expression of adaptive immune cells is significantly altered between non-injured, aged cystic mice, injury-accelerated cystic mice, and non-cystic controls. Deletion of all adaptive immune cells reduced cystic disease in the injury-accelerated model but had no effect on cystic disease in the non-injured model. This differential rescue may be due to unique adaptive immune cell subtypes and ligands that are only present in the injury accelerated model of cystic disease.

ORGANISM(S): Mus musculus

PROVIDER: GSE193528 | GEO | 2022/01/19

REPOSITORIES: GEO

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A comprehensive immune cell atlas of cystic kidney disease reveals the involvement of adaptive immune cells in injury mediated cyst progression

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