Mammary Gland microRNA profiling in female mice receiving flaxseed or its oil and secoisolariciresinol diglucoside components

ABSTRACT: Breast cancer is one of the most leading causes of cancer mortality in the world. A growing body of evidence demonstrates the association between flaxseed (FS) consumption and the reduction of breast cancer risk. Flaxseed (FS) is an oilseed rich in n-3 polyunsaturated fatty acids (PUFA), α-linolenic acid (ALA), in dietary phytoestrogen lignan, secoisolariciresinol diglucoside (SDG), and in fiber. Early-life exposure to FS or to its isolated components was associated with the improvement of the mammary gland (MG) morphogenesis and differentiation, and prevention of the MG carcinogenesis. Here, we investigated the effect of FS as a whole food and its isolated oil (FSO) and lignan (SDG) on the MG microRNA (miRNA) signature, in female mice at a late stage of development. We identified a diet-specific MG miRNA signature. Significantly deregulated miRNAs in response to the 3-weeks intervention were associated with breast cancer. Identified miRNAs targeted genes enriched in MG growth and development and in cancer. These miRNAs could be used as potential biomarkers for breast cancer.

ORGANISM(S): Mus musculus

PROVIDER: GSE193847 | GEO | 2022/03/16

REPOSITORIES: GEO