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Transcriptome of JAZF1-SUZ12 translocation

ABSTRACT: In this study, we characterize translocations that are frequent in Low Grade Endometrial Stromal Sarcoma (LG-ESS) and Ossifying FibroMyxoid Tumors (OFMT). We find that the fusion protein assembles a mega-complex harboring both NuA4/TIP60 and PRC2 subunits and enzymatic activities and leads to mislocalization of chromatin marks in the genome, linked to aberrant gene expression.

ORGANISM(S): Homo sapiens

PROVIDER: GSE196755 | GEO | 2022/02/18

REPOSITORIES: GEO

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