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A reference single-cell regulomic and transcriptomic map of cynomolgus monkeys

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Macaca fascicularis

PROVIDER: GSE196794 | GEO | 2022/06/27

REPOSITORIES: GEO

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A reference single-cell regulomic and transcriptomic map of cynomolgus monkeys.

Project description:Non-human primates are attractive laboratory animal models that accurately reflect both developmental and pathological features of humans. Here we present a compendium of cell types across multiple organs in cynomolgus monkeys (Macaca fascicularis) using both single-cell chromatin accessibility and RNA sequencing data. The integrated cell map enables in-depth dissection and comparison of molecular dynamics, cell-type compositions and cellular heterogeneity across multiple tissues and organs. Using single-cell transcriptomic data, we infer pseudotime cell trajectories and cell-cell communications to uncover key molecular signatures underlying their cellular processes. Furthermore, we identify various cell-specific cis-regulatory elements and construct organ-specific gene regulatory networks at the single-cell level. Finally, we perform comparative analyses of single-cell landscapes among mouse, monkey and human. We show that cynomolgus monkey has strikingly higher degree of similarities in terms of immune-associated gene expression patterns and cellular communications to human than mouse. Taken together, our study provides a valuable resource for non-human primate cell biology.

| S-EPMC9279386 | biostudies-literature

Infinium Monkeys: Infinium 450K array for the Cynomolgus macaque (Macaca fascicularis)

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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A reference single-cell regulomic and transcriptomic map of cynomolgus monkeys [RNA-seq]

Project description:Non-human primates (NHP) are attractive laboratory animal models that accurately reflect both developmental and pathological features of humans. Here we present a compendium of cell types from the cynomolgus monkey Macaca fascicularis (denoted as ‘Monkey Atlas’) using both single-cell chromatin accessibility (scATAC-seq) and RNA sequencing (scRNA-seq) data at the organism-wide level. The integrated cell map enables in-depth dissection and comparison of molecular dynamics, cell-type composition and cellular heterogeneity across multiple tissues and organs. Using single-cell transcriptomic data, we inferred pseudotime cell trajectories and cell-cell communications to uncover key molecular signatures underlying their cellular processes. Furthermore, we identified various cell-specific cis-regulatory elements and constructed organ-specific gene regulatory networks at the single-cell level. Finally, we performed a comparative analysis of single-cell landscapes among mouse, cynomolgus monkey and human, and we showed that cynomolgus monkey has significantly higher degree of cell-type similarity to human than mouse. Taken together, our study provides a valuable resource for NHP cell biology.

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A reference single-cell regulomic and transcriptomic map of cynomolgus monkeys

Project description:A reference single-cell regulomic and transcriptomic map of cynomolgus monkeys

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