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Altered expression of microRNAs in the myocardium of rats with acute myocardial infarction

ABSTRACT: MicroRNAs are important cellular components and their dysfunctions are associated with various disease. Acute myocardial infarction (AMI) is one of the most serious cardiovascular diseases. Although several miRNAs have been reported to be associated with AMI, more novel miRNAs are needed to be investigated to ascertain if they are associated with AMI.

ORGANISM(S): Mus musculus Rattus norvegicus Homo sapiens

PROVIDER: GSE19695 | GEO | 2010/01/05

SECONDARY ACCESSION(S): PRJNA121869

REPOSITORIES: GEO

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Altered expression of microRNAs in the myocardium of rats with acute myocardial infarction

Project description:MicroRNAs are important cellular components and their dysfunctions are associated with various disease. Acute myocardial infarction (AMI) is one of the most serious cardiovascular diseases. Although several miRNAs have been reported to be associated with AMI, more novel miRNAs are needed to be investigated to ascertain if they are associated with AMI. SD rats (180-200g) was divided into sham-control group and two days group after AMI, seven days group after AMI, fourteen days group after AMI, each group has six individual animals total RNA was taken from the border-zone myocardium , low molecular weight RNA was seperate and labeled , and then hybridized to capitalbio V2 biochip representing about 924 microRNA . three chip were test in each group, and the procedure was repeated twice.

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