Transcriptomics

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Somatic Cell Fate Maintenance in Mouse Fetal Testes via Autocrine/Paracrine Regulation of anti-Müllerian hormone and Activin B


ABSTRACT: Fate determination and maintenance of fetal testes in most mammals occur cell autonomously as a result of the action of key transcription factors in Sertoli cell. In the mouse testis AMH and Activin B are required for the maintenance of Sertoli cell fate. In the absence of both AMH and Activin B (in the global dKO) Sertoli cells at the testis poles transdifferentiate into granulosa cells by embryonic day 15.5.

ORGANISM(S): Mus musculus

PROVIDER: GSE196973 | GEO | 2022/05/12

REPOSITORIES: GEO

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