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Transcriptional profiling of DLBCL-like murine pBIC tumors (p53F/F; Blimp1F/F; IKK2castopF/stopF; Cg1Cre/+)

ABSTRACT: Germinal center (GC) B cells have been presented as the cell-of-origin of diffuse large B-cell lymphoma (DLBCL), and these cells can be functionally targeted with the use of Cgamma1-cre mice (Cg1cre) in wich the expression of Cre recombinase is induced by transcription of the Ig gamma1 constant region gene segment. Here, we aimed to develop and characterize novel immunocompetent multi-lesion mouse models of DLBCL that, by triggering genetic alterations specifically in GC B cells, recapitulate relatively fast the molecular, cellular and tumor microenvironment of aggressive human DLBCL.

ORGANISM(S): Mus musculus

PROVIDER: GSE197689 | GEO | 2023/03/06

REPOSITORIES: GEO

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