Transcriptomics

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Differentially expressed genes in Mettl3-deficient livers compared to control livers


ABSTRACT: Liver-specific deficiency of Mettl3 causes liver injury. By performing RNA sequencing (RNA-seq) analysis on the Mettl3-deficient versus control livers, we identified the potential target genes that were closely associated with the liver phenotype in liver-specific Mettl3 knockout mice. RNA-seq analysis revealed extensive metabolic reprogramming in Mettl3-deficient livers. These results demonstrated that Mettl3 coordinates metabolic homeostasis and functional maturation during postnatal liver development.

ORGANISM(S): Mus musculus

PROVIDER: GSE197800 | GEO | 2022/03/09

REPOSITORIES: GEO

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