Transcriptomics

Dataset Information

0

Glucagon-like Peptide-1 (GLP-1) Rescue Diabetic Cardiac Dysfuntions in Human iPSC-Derived Cardiomyocytes


ABSTRACT: We investigate the effects of GLP-1 on diabetic cardiomyocytes (DCMs) model established by human induced pluripotent stem cells-derived cardiomyocytes (iPSC-CMs). Two subtypes of GLP-1, GLP-17-36 and GLP-19-36, were evaluated for their efficacy on hypertrophic phenotype, impaired calcium homeostasis and electrophysiological properties. RNA-seq was performed to reveal the underlying molecular mechanism of GLP-1. Our results demonstrated that GLP-17-36 and GLP-19-36 were able to ameliorate high glucose-induced hypertrophy phenotype and cardiac dysfunctions in DCM model based on iPSC-CMs. Our study provides a novel platform to unveil the cellular mechanisms of diabetic cardiomyopathy, which sheds light on discovering better targets for novel therapeutic interventions.

ORGANISM(S): Homo sapiens

PROVIDER: GSE197850 | GEO | 2022/07/01

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

| PRJNA812513 | ENA
2024-09-30 | GSE248715 | GEO
2024-09-30 | GSE248714 | GEO
2024-08-26 | GSE275650 | GEO
2017-09-26 | GSE99814 | GEO
2023-11-16 | GSE208283 | GEO
2021-01-31 | GSE160991 | GEO
2018-12-01 | GSE99470 | GEO
2019-09-26 | GSE116127 | GEO
2022-12-09 | GSE211105 | GEO