Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Effect of human beta defensin-2 (hBD-2) on T cells [human]

ABSTRACT: In this experiment, we studied how human beta defensin-2 (hBD-2) affects kinase activity of T cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE198402 | GEO | 2022/12/20

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Effect of human beta defensin-2 (hBD-2) on T cells [mouse]

Project description:In this experiment, we studied how human beta defensin-2 (hBD-2) affects kinase activity of T cells.

2022-12-20 | GSE198404 | GEO

Effect of human beta defensin-2 (hBD-2) on T cells

Project description:In this experiment, we studied how human beta defensin-2 (hBD-2) affects gene expression of T cells. Murine splenic C57BL/6 CD4/CD8 T cells were stimulated with anti-CD3/anti-CD28 beads and hBD-2 or vehicle (PBS) control for 48h before RNA isolation

2022-12-23 | GSE190797 | GEO

Effect of human beta defensin-2 (hBD-2) on T cells

Project description:Effect of human beta defensin-2 (hBD-2) on T cells

| PRJNA788487 | ENA

Effect of human beta defensin-2 (hBD-2) on T cells

Project description:Effect of human beta defensin-2 (hBD-2) on T cells

| PRJNA814890 | ENA

Effect of human beta defensin-2 (hBD-2) on T cells [human]

Project description:Effect of human beta defensin-2 (hBD-2) on T cells [human]

| PRJNA814888 | ENA

Effect of human beta defensin-2 (hBD-2) on T cells [mouse]

Project description:Effect of human beta defensin-2 (hBD-2) on T cells [mouse]

| PRJNA814892 | ENA

Effect of human beta defensin-2 (hBD-2) on T cells

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-12-20 | GSE198405 | GEO

Human β-Defensin 2 (HBD-2) Displays Oncolytic Activity but Does Not Affect Tumour Cell Migration.

Project description:Defensins form an integral part of the cationic host defence peptide (HDP) family, a key component of innate immunity. Apart from their antimicrobial and immunomodulatory activities, many HDPs exert multifaceted effects on tumour cells, notably direct oncolysis and/or inhibition of tumour cell migration. Therefore, HDPs have been explored as promising anticancer therapeutics. Human β-defensin 2 (HBD-2) represents a prominent member of human HDPs, being well-characterised for its potent pathogen-killing, wound-healing, cytokine-inducing and leukocyte-chemoattracting functions. However, its anticancer effects remain largely unknown. Recently, we demonstrated that HBD-2 binds strongly to phosphatidylinositol-4,5-bisphosphate (PI(4,5)P2), a key mediator of defensin-induced cell death and an instructional messenger during cell migration. Hence, in this study, we sought to investigate the lytic and anti-migratory effects of HBD-2 on tumour cells. Using various cell biological assays and confocal microscopy, we showed that HBD-2 killed tumour cells via acute lytic cell death rather than apoptosis. In addition, our data suggested that, despite the reported PI(4,5)P2 interaction, HBD-2 does not affect cytoskeletal-dependent tumour cell migration. Together, our findings provide further insights into defensin biology and informs future defensin-based drug development.

| S-EPMC8961614 | biostudies-literature

Human beta defensin (HBD) gene copy number affects HBD2 protein levels: impact on cervical bactericidal immunity in pregnancy.

Project description:Human beta defensin 2 (HBD2) is an endogenous mucosal antimicrobial peptide (AMP) upregulated during infection and inflammation. HBD2 is encoded by the DEFB4 gene, which exhibits extensive copy number variation. Previous studies have demonstrated a relationship between HBD copy number and serum HBD2 protein levels; however, our current understanding of the influence of copy number on mucosal AMP function remains limited. This study explores the relationship between HBD copy number, cervicovaginal HBD2 protein levels and antimicrobial activity in 203 women with risk factors for preterm birth. We provide evidence that suggests HBD copy number modulates cervical antimicrobial immunity.

| S-EPMC5831986 | biostudies-literature

Human Beta Defensin 2 Ameliorated Alcohol-Associated Liver Disease in Mice

Project description:Human Beta Defensin 2 in Alcohol-Associated Liver Disease

| PRJEB49248 | ENA