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Full-length transcriptome sequencing reveals gene expression signatures in human soft tissue sarcomas

ABSTRACT: Soft tissue sarcomas (STSs) are heterogeneous malignancies derived from mesenchymal cells. Due to its rarity, heterogeneity, and limited overall response to chemotherapy, STSs represents a therapeutic challenge. Necroptosis is a novel therapeutic strategy for enhancing immunotherapy of cancer. Nevertheless, no research has explored the relationship between necroptosis-related genes (NRGs) and STSs.We performed full-length transcriptome analysis of four pairs of soft-tissue sarcomas and normal normal adjacent tissues. We further validated the expression level of necroptosis-related genes (NRGs) in these sample pairs.

ORGANISM(S): Homo sapiens

PROVIDER: GSE198568 | GEO | 2022/05/05

REPOSITORIES: GEO

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