Proteomics

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The Proteomic Landscape of Soft Tissue Sarcomas

ABSTRACT: Soft tissue sarcomas (STS) are rare and diverse mesenchymal cancers with limited treatment options. Here we undertake comprehensive proteomic profiling of formalin-fixed paraffin embedded tumour specimens from 321 STS patients representing 11 histological subtypes.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Paul Huang  

LAB HEAD: Paul Huang

PROVIDER: PXD036226 | Pride | 2023-05-09

REPOSITORIES: Pride

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20180709_LK_Huang_lab_LMS_set01.msf Msf
20180709_LK_Huang_lab_LMS_set01_F1.raw Raw
20180709_LK_Huang_lab_LMS_set01_F10.raw Raw
20180709_LK_Huang_lab_LMS_set01_F2.raw Raw
20180709_LK_Huang_lab_LMS_set01_F3.raw Raw
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Publications

Soft tissue sarcomas (STS) are rare and diverse mesenchymal cancers with limited treatment options. Here we undertake comprehensive proteomic profiling of tumour specimens from 321 STS patients representing 11 histological subtypes. Within leiomyosarcomas, we identify three proteomic subtypes with distinct myogenesis and immune features, anatomical site distribution and survival outcomes. Characterisation of undifferentiated pleomorphic sarcomas and dedifferentiated liposarcomas with low infiltr  ...[more]

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