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Single-cell RNA sequencing reveals the impact of CD34+ cells in heart failure

ABSTRACT: CD34+ cells have been used to treat the patients with heart failure, but the outcome is variable. It is of great significance to scrutinize the fate and the mechanism of CD34+ cell differentiation in vivo during heart failure and explore its intervention strategy. By analyzing the transcriptomes of single cells from the Cd34-CreERT2;R26-tdTomato heart, we illustrated the dynamics of cell landscape during the progression of heart hypertrophy, including CD34+ cells, fibroblasts, endothelial cells and immune cells. And Our study also provides a cellular landscape of CD34+ cell-derived cells in the hypertrophy heart of animal models.

ORGANISM(S): Mus musculus

PROVIDER: GSE198833 | GEO | 2022/10/06

REPOSITORIES: GEO

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