Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Single-cell RNA sequencing for heart failure heart with the history of hypertension

ABSTRACT: CD34+ stem cells have been used to treat the patients with heart failure, but the outcome is variable. It is of great significance to scrutinize the fate and the mechanism of CD34+ cell differentiation in vivo during heart failure and explore its intervention strategy.

ORGANISM(S): Homo sapiens

PROVIDER: GSE222144 | GEO | 2023/01/08

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Single-cell RNA sequencing reveals the impact of CD34+ cells in heart failure

Project description:CD34+ cells have been used to treat the patients with heart failure, but the outcome is variable. It is of great significance to scrutinize the fate and the mechanism of CD34+ cell differentiation in vivo during heart failure and explore its intervention strategy. By analyzing the transcriptomes of single cells from the Cd34-CreERT2;R26-tdTomato heart, we illustrated the dynamics of cell landscape during the progression of heart hypertrophy, including CD34+ cells, fibroblasts, endothelial cells and immune cells. And Our study also provides a cellular landscape of CD34+ cell-derived cells in the hypertrophy heart of animal models.

2022-10-06 | GSE198833 | GEO

Single-cell RNA sequencing for heart failure heart with the history of hypertension

Project description:Single-cell RNA sequencing for heart failure heart with the history of hypertension

| PRJNA918371 | ENA

INO80 and heart failure.

Project description:INO80 and heart failure.

| PRJNA1002579 | ENA

Heart Failure with Preserved Ejection Fraction - Mouse Heart and Lung Tissue & Comorbidities

Project description:FASILOX analysis of heart and lung tissue form mice with heart failure with preserved ejection fraction and several comorbidities.

2024-10-02 | PXD056447 | JPOST Repository

Single-cell RNA sequencing for heart failure with a history of coronary heart disease and hypertension

Project description:Single-cell RNA sequencing for heart failure with a history of coronary heart disease and hypertension

| PRJNA1038742 | ENA

Epigenetic gene-expression links heart failure to memory impairment [rnaseq_from_MI_experiment]

Project description:In current clinical practice care of diseased patients is often restricted to separated disciplines. However, such an organ-centered approach is not always suitable. For example, cognitive dysfunction is a severe burden in heart failure patients. Moreover, these patients have an increased risk for age-associated dementias. The underlying molecular mechanisms are presently unknown and thus corresponding therapeutic strategies to improve cognition in heart failure patients are missing. Using mice as model organisms we show that heart failure leads to specific changes in hippocampal gene-expression, a brain region intimately linked to cognition. These changes reflect increased cellular stress pathways which eventually lead to loss of neuronal euchromatin and reduced expression of a hippocampal gene cluster essential for cognition. Consequently, mice suffering from heart failure exhibit impaired memory function. These pathological changes are ameliorated via the administration of a drug that promotes neuronal euchromatin formation. Our study provides first insight to the molecular processes by which heart failure contributes to neuronal dysfunction and point to novel therapeutic avenues to treat cognitive defects in heart failure patients.

2020-12-01 | GSE159442 | GEO

Epigenetic gene-expression links heart failure to memory impairment [chipseq_from_saha_treatment]

2020-12-01 | GSE159475 | GEO

Epigenetic gene-expression links heart failure to memory impairment [smallrna_after_saha]

2020-12-01 | GSE159447 | GEO

Epigenetic gene-expression links heart failure to memory impairment [rnaseq_tunicamycin_6h]

2020-12-01 | GSE159446 | GEO

Epigenetic gene-expression links heart failure to memory impairment [rnaseq_after_saha]

2020-12-01 | GSE159441 | GEO