Genomics

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Genome-wide analysis of RB and p130 binding in human diploid fibroblasts


ABSTRACT: The action of RB as a tumor suppressor has been difficult to define, in part, due to the redundancy of the related proteins p107 and p130. By coupling advanced RNAi technology with a genome wide analysis of gene expression and RB chromatin binding, we identified a unique and specific activity of RB in repressing DNA replication as cells exit the cell cycle into senescence, a tumor suppressive program.

ORGANISM(S): Homo sapiens

PROVIDER: GSE19898 | GEO | 2010/01/15

SECONDARY ACCESSION(S): PRJNA124023

REPOSITORIES: GEO

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