Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Agustin Chicas
PROVIDER: E-GEOD-19898 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Chicas Agustin A Wang Xiaowo X Zhang Chaolin C McCurrach Mila M Zhao Zhen Z Mert Ozlem O Dickins Ross A RA Narita Masashi M Zhang Michael M Lowe Scott W SW
Cancer cell 20100401 4
The RB protein family (RB, p107, and p130) has overlapping and compensatory functions in cell-cycle control. However, cancer-associated mutations are almost exclusively found in RB, implying that RB has a nonredundant role in tumor suppression. We demonstrate that RB preferentially associates with E2F target genes involved in DNA replication and is uniquely required to repress these genes during senescence but not other growth states. Consequently, RB loss leads to inappropriate DNA synthesis fo ...[more]