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The steroid hormone estriol (E3) regulates epigenetic programming of fetal mouse brain and reproductive tract [NimbleGen]

ABSTRACT: We identify an unexpected functional role for E3 in fetal reproductive system and brain. We further identify a novel mechanism of estrogen action, through recruitment of epigenetic modifiers to estrogen receptors and their target genes, which doesn’t correlated with the traditional view of estrogen potency.

ORGANISM(S): Mus musculus

PROVIDER: GSE199213 | GEO | 2023/03/23

REPOSITORIES: GEO

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The steroid hormone estriol (E3) regulates epigenetic programming of fetal mouse brain and reproductive tract [Affymetrix]

Project description:We identify an unexpected functional role for E3 in fetal reproductive system and brain. We further identify a novel mechanism of estrogen action, through recruitment of epigenetic modifiers to estrogen receptors and their target genes, which doesn’t correlated with the traditional view of estrogen potency.

2023-03-23 | GSE199174 | GEO

The steroid hormone estriol (E3) regulates epigenetic programming of fetal mouse brain and reproductive tract [methylation]

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The steroid hormone estriol (E3) regulates epigenetic programming of fetal mouse brain and reproductive tract [ChIP-Seq]

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The steroid hormone estriol (E3) regulates epigenetic programming of fetal mouse brain and reproductive tract

Project description:This SuperSeries is composed of the SubSeries listed below.

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The steroid hormone estriol (E3) regulates epigenetic programming of fetal mouse brain and reproductive tract [NimbleGen]

Project description:The steroid hormone estriol (E3) regulates epigenetic programming of fetal mouse brain and reproductive tract [NimbleGen]

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The steroid hormone estriol (E3) regulates epigenetic programming of fetal mouse brain and reproductive tract

Project description:The steroid hormone estriol (E3) regulates epigenetic programming of fetal mouse brain and reproductive tract

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The steroid hormone estriol (E3) regulates epigenetic programming of fetal mouse brain and reproductive tract [Affymetrix]

Project description:The steroid hormone estriol (E3) regulates epigenetic programming of fetal mouse brain and reproductive tract [Affymetrix]

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The steroid hormone estriol (E3) regulates epigenetic programming of fetal mouse brain and reproductive tract [methylation]

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The steroid hormone estriol (E3) regulates epigenetic programming of fetal mouse brain and reproductive tract [ChIP-Seq]

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Preferential Epigenetic Programming of Estrogen Response after in utero xenoestrogen (bisphenol-A) exposure [NimbleGen]

Project description:Bisphenol-A (BPA) is an environmentally ubiquitous estrogen-like endocrine-disrupting compound. Exposure toBPAin utero hasbeen linked tofemale reproductive disorders, including endometrial hyperplasiaandbreast cancer. Estrogens are an etiological factor in many of these conditions. We sought to determine whether in utero exposure to BPA altered the globalCpGmethylation pattern of the uterine genome, subsequent gene expression, and estrogen response.Pregnantmicewere exposed to an environmentally relevant dose of BPAorDMSOcontrol.Uterine DNAand RNAwere examined by usingmethylatedDNAimmunoprecipitationmethylation microarray, expression microarray, and quantitative PCR. In utero BPA exposure altered the global CpG methylation profile of the uterine genome and subsequent gene expression. The effect on gene expression was not apparent until sexual maturation, which suggested that estrogen response was the primary alteration. Indeed, prenatal BPA exposure preferentially altered adult estrogen-responsive gene expression. Changes in estrogen response were accompanied by altered methylation that preferentially affected estrogen receptor-a (ERa)–binding genes. The majority of genes that demonstrated both altered expression and ERa binding had decreased methylation. BPA selectively altered the normal developmental programming of estrogen-responsive genes via modification of the genes that bind ERa. Gene– environment interactions driven by early life xenoestrogen exposure likely contributes to increased risk of estrogenrelateddisease in adults.—Jorgensen, E. M.,Alderman,M.H., III,Taylor, H. S. Preferential epigenetic programmingof estrogen response after in utero xenoestrogen (bisphenol-A) exposure.

2016-10-24 | GSE89125 | GEO

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