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Transcriptome-wide identification of STING agonist programed B cells

ABSTRACT: We employed RNA-seq to study the transcriptomic change in B lymphocytes in response to STING agonist. Transcriptomic analysis of wild type and TMEM173–/– B cells stimulated with STING agonist revealed that the inflammatory response pathway enriched in 3'3'-cGAMP treated WT B cells but lacking in Tmem173-/-B cells comprised of a cluster containing inhibitory regulators, provoking STING signal to evade immune surveillance by inducing an immunosuppressive B cell population.

ORGANISM(S): Mus musculus

PROVIDER: GSE199343 | GEO | 2022/08/10

REPOSITORIES: GEO

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