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The transcriptome alteration in tumoral NK cells in response to dual or monotherapy of STING agonist and IL-35 blocking antibodies

ABSTRACT: To investigate the role of STING agonist and IL-35 blocking antibodies in the regulation of NK cell function, tumor-infiltrated NK cells were flow cytometrically separated from control (IgG), cGAMP, anti-IL-35, or combination treated groups We performed gene expression profiling analysis using data obtained from RNA-seq of tumor-infiltrated NK cells sorted from four groups.

ORGANISM(S): Mus musculus

PROVIDER: GSE211386 | GEO | 2022/08/21

REPOSITORIES: GEO

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