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Inactivation of Sirt6 ameliorates muscular dystrophy in mdx mice by releasing suppression of utrophin expression

ABSTRACT: In this study, Pax7-Cre mediated inactivation of Sirt6 in mdx mice resulted in profound improvement of the mdx phenotype at the functional level. To study the underlying molecular mechanisms and identify specific Sirt6 targets irrespectively to mdx mutation, we performed RNA-seq of freshly isolated muscle stem cells from control and Sirt6mKO mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE199487 | GEO | 2022/05/12

REPOSITORIES: GEO

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Transcriptome profiling of muscle from control, mdx and Sirt6 knockout on mdx background mice

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Inactivation of Sirt6 ameliorates muscular dystrophy in mdx mice by releasing suppression of utrophin expression.

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Transcriptomic analysis of mdx mouse muscles reveals a signature of early human Duchenne muscular dystrophy

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