Cell type specific gene expression analysis in pre-symptomatic huntington's disease.
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ABSTRACT: Selective neuronal vulnerability is a common, yet poorly understood characteristic of neurodegenerative diseases and is particularly prominent in Huntington's disease (HD). To determine how presence of mutant prion protein influences gene expression at pre-symptomatic stages, we used RiboTag to isolate cell type-specific, translating RNA from GABAergic, glutamatergic, somatostatin- (SST) and parvalbumin-expressing neurons of 9-month-old knock-in mice of heterozygous for a Q185 expansion in the endogenous Hdh gene or littermate controls.
ORGANISM(S): Mus musculus
PROVIDER: GSE199837 | GEO | 2022/11/04
REPOSITORIES: GEO
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