Transcriptomics

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Cell type specific gene expression analysis in pre-symptomatic huntington's disease.


ABSTRACT: Selective neuronal vulnerability is a common, yet poorly understood characteristic of neurodegenerative diseases and is particularly prominent in Huntington's disease (HD). To determine how presence of mutant prion protein influences gene expression at pre-symptomatic stages, we used RiboTag to isolate cell type-specific, translating RNA from GABAergic, glutamatergic, somatostatin- (SST) and parvalbumin-expressing neurons of 9-month-old knock-in mice of heterozygous for a Q185 expansion in the endogenous Hdh gene or littermate controls.

ORGANISM(S): Mus musculus

PROVIDER: GSE199837 | GEO | 2022/11/04

REPOSITORIES: GEO

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