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Human blood expression for Huntington's disease versus control

ABSTRACT: Affymetrix U133A expression levels for 12 symptomatic and 5 presymptomatic Huntington's disease patients versus 14 healthy controls. Keywords: other

ORGANISM(S): Homo sapiens

SUBMITTER: Dimitri Krainc

PROVIDER: E-GEOD-1751 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Genome-wide expression profiling of human blood reveals biomarkers for Huntington's disease.

Borovecki F F Lovrecic L L Zhou J J Jeong H H Then F F Rosas H D HD Hersch S M SM Hogarth P P Bouzou B B Jensen R V RV Krainc D D

Proceedings of the National Academy of Sciences of the United States of America 20050725 31

Huntington's disease (HD) is an autosomal dominant disorder caused by an expansion of glutamine repeats in ubiquitously distributed huntingtin protein. Recent studies have shown that mutant huntingtin interferes with the function of widely expressed transcription factors, suggesting that gene expression may be altered in a variety of tissues in HD, including peripheral blood. Affymetrix and Amersham Biosciences oligonucleotide microarrays were used to analyze global gene expression in blood samp ...[more]

PMID: 16043692

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