Transcriptomics

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RNA-seq of homogenized lungs of APOE knock-in mice during COVID-19 III


ABSTRACT: Here we analyze the transcriptional profiles of homogenized lungs resected from young female APOE2, APOE3, and APOE4 knock-in mice on day 4 post infection with SARS-CoV-2 MA10. Weighted gene co-expression analysis identified gene modules enriched for genes implicated in T and B cell activation to be downregulated in APOE2 and APOE4 mice during COVID-19 progression.

ORGANISM(S): Mus musculus

PROVIDER: GSE200132 | GEO | 2022/08/07

REPOSITORIES: GEO

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