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Aldose reductase inhibition decelerates optic nerve degeneration by suppressing retinal microglia activation

ABSTRACT: To investigate the role of aldose reductase (AR) inhibition using Sorbinil on retinal microglia (RMG) activation, retinal ganglion cell (RGC) survival, and axon regeneration after optic nerve trauma. We observed that AR inhibition using Sorbinil attenuates RMG activation and subsequently promotes RGC survival and delays axon degeneration one week after optic nerve crush.

ORGANISM(S): Mus musculus

PROVIDER: GSE200233 | GEO | 2023/04/05

REPOSITORIES: GEO

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Gene expression timecourse in zebrafish whole eye in response to optic nerve crush

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