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Immunomodulation by the combination of statin and matrix-bound nanovesicle enhances optic nerve regeneration

ABSTRACT: To identify a novel clinically-relevant therapy, fluvastatin and matrix bound nanovesicles (MBV) were focused in this study. We found that fluvastatin and MBV synergistically enhance optic nerve regeneration and RGC protection after optic nerve injury in mouse. To identify the molecular mechanisms underlying enhancement of RGC protection and axon regeneration after optic nerve injury, bulk RNA sequencing analysis of the whole retina treated with MBV, fluvastatin and the combination of MBV and fluvastatin or PBS as a control two days after optic nerve crush, was performed. Bulk RNA-seq analysis revealed that genes and cellular pathways related to inflammation, were robustly altered.

ORGANISM(S): Mus musculus

PROVIDER: GSE226780 | GEO | 2024/06/05

REPOSITORIES: GEO

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Aldose reductase inhibition decelerates optic nerve degeneration by suppressing retinal microglia activation

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