Transcriptomics

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NLRP3 deficiency reverts intratumoral T cell exhaustion


ABSTRACT: CD8+ T cells derived from mice with intact NLRP3 signaling in the tumor microenvironment showed an increased expression of coinhibitory receptors PD-1, TIM-3, 2B4 and LAG-3 compared to CD8+ T cells from PancOVA-bearing Nlrp3-/- mice, indicating that NLRP3 inflammasome activation in the tumor microenvironment mediates IL-18 receptor signaling-induced T cell exhaustion. RNAseq was used to characterised molecular pathways involved in T cell plasticity in the presence and absence of intratumoral NLRP3.

ORGANISM(S): Mus musculus

PROVIDER: GSE200570 | GEO | 2022/04/14

REPOSITORIES: GEO

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